摘要
乳腺癌转移抑制基因1(breast cancer metastasis suppressor 1,BRMS1)是2000年在乳腺癌细胞中发现的一种肿瘤转移抑制基因,他可降低肿瘤细胞的转移潜能,却不影响肿瘤本身的生长.随后发现其在黑色素瘤、膀胱癌、嗜铬细胞瘤、卵巢癌、非小细胞肺癌、子宫内膜癌、鼻腔副鼻窦癌转移中均呈低表达或不表达.近年来又发现BRMS1在口腔鳞癌、胃癌、肝癌、胆囊癌、胰腺癌等消化系肿瘤转移中也起到抑制作用.恶性肿瘤已经成为危害人类健康最严重的疾病之一,在我国以消化系肿瘤最常见;对BRMS1作用机制的深入研究,必将为肿瘤转移的分子诊断、靶向治疗和预后提供潜在的理论依据及广泛的应用前景.现就近年来BRMS1在消化系肿瘤中的相关研究进展作一综述.
Breast cancer metastasis suppressor 1（BRMS1） is a tumor metastasis suppressor discovered in breast carcinoma cells in 2000.It can reduce the metastasis potential of tumor cells without affecting the growth of orthotopic tumor.BRMS1 is lowly expressed or not at all in metastases of melanoma,bladder carcinoma,pheochromocytoma,ovarian cancer,non-small cell lung cancer,endometrial cancer,nasal and paranasal sinus carcinoma.Malignant tumors have become one of the most serious diseases endangering human health,and digestive system neoplasms are the most common malignant tumors in China.Elucidation of the role of BRMS1 will certainly provide a potential theoretical basis for the molecular diagnosis,targeted therapy,and prognosis evaluation of tumor metastases.In this review,we will summarize recent progress in understanding the role of BRMS1 in digestive system neoplasms.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第27期2583-2588,共6页
World Chinese Journal of Digestology
关键词
乳腺癌转移抑制基因1
消化系肿瘤
转移
机制
靶向治疗
Breast cancer metastasis suppressor 1
Digestive system neoplasms
Metastasis
Mechanism
Targeted therapy
