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肿瘤转移抑制基因BRMS1的研究进展

Progress in metastasis suppressor gene BRMS1
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摘要 肿瘤转移抑制基因是指抑制肿瘤细胞转移而不影响原发肿瘤生长的基因。乳腺癌转移抑制基因1(BRMS1)是在2000年新发现的转移抑制基因,现已发现它能抑制多种肿瘤细胞的转移。本文就BRMS1的基因结构、生物学功能及与多种肿瘤的关系、作用机制及其临床意义作一综述。 Genes that inhibit metastasis without affecting primary tumor formation at the primary site are known as metastasis suppressor gene. Breast cancer metastasis suppressor 1 （ BRMS1 ） was identified as a new metastasis suppressor geue in 2000. Docu- mented studies have confirmed that BRMS1 is a potent metastasis suppressor in many types of tumor not limited to breast cancer. In this review, we provide an overview of its biology function, the relationships with tumor metastasis, action mechanism and clinical signifi- cance.
作者 高尔立 林志远 杨银龙
机构地区 温州医学院附属第一医院肿瘤外科 上海市第五人民医院泌尿外科
出处 《临床肿瘤学杂志》 CAS 2013年第2期174-178,共5页 Chinese Clinical Oncology
基金 浙江省医药卫生科技计划项目(2011KYA108) 温州市科技计划项目(Y20110065)
关键词 乳腺癌转移抑制基因1 转移 预后 Breast cancer metastasis suppressor 1 Metastasis Prognosis
分类号 R730 [医药卫生—肿瘤]
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参考文献35

  • 1Seraj M J, Samant RS, Verderame M, et al. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 1 lq13 [ J]. Cancer Rcs, 2000, 60( 11 ) :2764 - 2769.
  • 2Cicek M, Samant RS, Kinter M, et al. Identification of metasta- sis associated proteins through protein analysis of metastatic MDA- MB-435 and metastasis suppressed BRMS1 transfected-MDA-MB- 435 cells[J]. Clin Exp Metastasis, 2004, 21 (2) : 149 -157.
  • 3Hurst DR, Xie Y, Edmonds MD, et al. Multiple forms of BRMSI are differentially expressed in the MCF10 isogenic breast cancer progression model [ J ]. Clin Exp Metastasis, 2009, 26 (2) :89 -96.
  • 4Zhang Z, Yamashita H, Toyama T, et al. Reduced expression of the breast cancer metastasis suppressor 1 mRNA is correlated with poor progress in breast cancer[J]. Clin Cancer Res, 2006, 12 (21) :6410.
  • 5Hicks DG, Yoder BJ, Short S, et al. Loss of breast cancer metas- tasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients [.I ]. Clin Cancer Res, 2006, 12(22) :6702 -6708.
  • 6Lombardi G, Di Cristofano C, Capodanno A, et al. High level of message RNA for BRMSI in primary breast carcinomas is associat- ed with poor prognosis[J]. Int J Cancer, 2007, 120 (6) : 1169 - 1178.
  • 7Kelly LM, Buggy Y, Hill A, et al. Expression of the breast canc- er metastasis suppressor gene, BRMSI, in human breast carcino- ma: lack of correlation with metastasis to axillary lymph nodes [J]. Tumour Biol, 2005,26(4) :213 -216.
  • 8Frolova N, Edmonds MD, Bodcnstine TM, et al. A shift from nu- clear to cytoplasmic breast cancer metastasis suppressor 1 expres- sion is associated with highly proliferative estrogen receptor-nega- tive breast cancer[ J]. Tumour Biol, 2009, 30(3) :148 -159.
  • 9Li J, Cheng Yi, Tai D, et al. Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis [J].Oncogene, 2010, 30(8) : 896 -906.
  • 10Slipicevic A, Holm R, Emilsen E, et al. Cytoplasmic BRMSI expression in malignant melanoma is associated with increased disease-free survival[ J]. BMC Cancer, 2012, 12( 1 ) :73.
临床肿瘤学杂志
2013年 第2期

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