摘要
目的 为了探讨神经肌肉怀疾病的发病与线粒体ＤＮＡ突变的关系。方法 采用ＰＣＲ技术检测１８例患有不同神经肌肉性疾病患者的外周血和骨骼肌细胞中的线粒体ＤＮＡ。结果 其中５例患者有ｍｔＤＮＡ５２６ｂｐ段缺失，此缺失区于线粒体呼吸链复合物的编码区。结论 表明该突变对神经肌肉性疾病的发生有一定作用。
Objective:To understand the relation to mechanism of neuromuscular disease and mtDNA mutation.Methods:using PCR technique,we investigated blood and or skeletal muscle of 18 patients with neuromuscular diseases.Results:A deletion in the length of 526 bp was found in blood mitochondrial DNA of 5 patients with neuromuscular disease.The deletion region partially lies in the coding region of respiratory cham complex.Conclusion:It is suggested that this mutation is related to neuromuscular diseases.
出处
《福建医药杂志》
CAS
2000年第3期99-100,共2页
Fujian Medical Journal
基金
福建医科大学苗圃资金资助
