摘要
目的探讨原发性高血压患者β2肾上腺素能受体基因单核苷酸多态性与高血压发生及缬沙坦治疗的关系。方法应用直接测序方法对80例原发性高血压患者(EH组)与40例体检健康者(对照组)β2肾上腺素能受体基因作单核苷酸多态性分型。结果 2组β2肾上腺素能受体AA,AG,GG基因型比较差异无统计学意义(P>0.05);EH组G等位基因频率明显高于对照组,差异有统计学意义(P<0.05);β2肾上腺素能受体等位基因分布频率在缬沙坦用药前、后血压变化上差异无统计学意义(P>0.05)。结论β2肾上腺素能受体基因与原发性高血压发病有关。
Objective To study the correlation between single nueleotide polymorphisms of β2 adrenergic receptor and antihypertensive effect of valsartan on patients with essential hypertension. Methods Direct DNA sequencing was performed in 80 patients with essential hypertension （EH group） and 40 health controls （control group） to detect the single nueleotide polymorphisms of β2 adrenergic receptor. Results There was no significant difference in AA, AG or GG genotype of β2 adrenergic receptor between EH group and control group （P〉0.05）. G allele frequency in EH group was obviously higher than that in control group （P〈0.05）. The allele genotype frequency did not differ significantly with the changes of blood pressure after being treated with valsartan （P〉 0.05）. Conclusion β2 adrenergic receptor might be involved in the development of essential hypertension.
出处
《中华实用诊断与治疗杂志》
2012年第10期949-950,954,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
南京军区医学科技创新课题(08MB129)
