摘要
目的探讨贯叶连翘治疗脑卒中后抑郁的临床疗效及安全性。方法检索并选取1978～2011国内外公开发表的有关贯叶连翘治疗脑卒中后抑郁的临床随机对照试验文献,并用RevMan5.0软件进行Meta分析。结果共有10项研究符合纳入标准①抑郁疗效改善方面的比较:与常规抗抑郁药组比较,贯叶连翘治疗脑卒中后抑郁在抑郁疗效功能改善方面有效率无显著性差异(P>0.05)。与常规治疗组比较,贯叶连翘治疗脑卒中后抑郁在抑郁疗效功能改善方面有效率有显著性差异(P<0.05);②神经功能恢复方面的比较:与常规抗抑郁药组比较,贯叶连翘组治疗脑卒中后抑郁在神经功能恢复方面有效率有显著性差异(P<0.05)。与常规治疗组比较,贯叶连翘组治疗脑卒中后抑郁在神经功能恢复方面有效率有显著性差异(P<0.05)。结论①在治疗脑卒中后的抑郁疗效改善方面,贯叶连翘组与常规抗抑郁药疗效相当,与常规治疗组比较疗效显著。②在神经功能恢复方面,贯叶连翘组与常规抗抑郁药组和常规治疗组比较,疗效均显著。
Objective The purpose of this systematic review with meta-analysis was to evaluate the difference of efficacy and side effect of St.John’s wort extract（Neurostan） in the treatment of post-stroke depression.Methods The related reports concerning the clinical trials of St.John’s wort extract（Neurostan） in treating post stroke depression published domestically and abroad between 1978 and 2011 were searched and Meta analysis was conducted on the selected reports by means of Review Manager 5.0.Results There are 11 reports matches our including standards.①Treatment effects on PSD symptoms： Compared with conventional antidepressants,the efficiency of St.John’s wort extract in treatment of post stroke depression has no significant variance（P 〉 0.05）.Compared with conventional therapy,the efficiency of st.John’s wort extract in the treatment of post stroke depression has significant variance（P ﹤ 0.05）.②Treatment effects on neurologic impairment： Compared with conventional antidepressants,the efficiency of St.John’s wort extract in treatment of post stroke depression has significant variance（P ﹤ 0.05）.Compared with conventional therapy,the efficiency of St.John ’s wort extract in treatment of post stroke depression has significant variance（P ﹤ 0.05）.Conclusion ①Treatment effects of St.John’s wort extract（Neurostan） on PSD symptoms： compared with conventional antidepressants,the efficiency is considerable.Compared with conventional therapy,the efficiency is better.②Treatment effects on neurologic impairment： compared with both conventional antidepressants and conventional therapy,the efficiency is better.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2012年第9期2133-2136,共4页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.81072613)
关键词
脑卒中
抑郁
贯叶连翘
META分析
Post - stroke depression
Depression
St. John＇s wort extract
Meta - analysis
