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缺氧诱导因子在慢性肾脏疾病进展中的作用 被引量：1

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摘要 全世界约10％的人群患有不同程度的慢性肾脏疾病（CKD），我国CKD的患病率也高达6．6％-13．8％。CKD的高发病率加上发展至终末期肾脏疾病（ESRD）和出现心脑血管疾病风险增加，使其成为威胁人类健康的重大疾病之一。缺氧诱导因子（HIF）是一种核转录因子，可以在缺氧的状态下调节多种基因的转录，参与对缺氧的适应性调节，近年来发现其在急性肾损伤（AKI）中具有肾保护作用而引起重视。但是HIF在CKD中的作用尚存在争议，本文将对HIF的特点、调节机制及其在CKD发生发展中的作用进行综述。
作者 王颖 陈丽萌 李学旺
机构地区 中国医学科学院北京协和医学院北京协和医院肾内科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2012年第9期740-743,共4页 Chinese Journal of Nephrology
关键词 缺氧诱导因子 慢性肾脏疾病 疾病进展 适应性调节 终末期肾脏疾病 核转录因子 肾保护作用 急性肾损伤
分类号 R692 [医药卫生—泌尿科学]
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参考文献44

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二级参考文献31

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共引文献21

同被引文献52

  • 1邹敏书,何威逊,余健,聂国明.抗Thy-1肾小球肾炎大鼠抗-MIF对TGF-β1表达的影响[J].临床肾脏病杂志,2006,6(6):274-277. 被引量：5
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中华肾脏病杂志
2012年 第9期

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