摘要
Toll样受体(TLRs)是机体固有免疫系统的受体之一,外界微生物可与TLRs结合并激活固有免疫、炎性反应,并进一步启动获得性免疫反应。近年研究发现一些内源性配体也可与TLRs结合,激活炎性反应。近年来,糖尿病的发生率逐年递增,由此导致的糖尿病肾病(DN)成为导致终末期肾脏疾病最主要的原因之一。目前对于TLRs与DN关系的研究较少,仅限于TLR2和TLR4。研究表明,TLR2和TLR4可通过介导代谢性炎性反应而调节糖尿病及DN的发生、发展过程。
Toll-like receptors（TLRs） is one of the receptors of innate immunity systems. TLRs can activate innate immunity and inflammation response by binding microorganisms, and further trigger and induce acquired immunity response. The studies in recent years have shown TLRs can bind with endogenic ligands to activate inflammation response. In recent years, the incidence rate of diabetes mellitus increases progressively, and diabetic nephropathy （DN） induced by diabetes has become one of the most common cau- ses of end-stage renal diseases. However, there are few studies about role of TLRs in DN,which are only lim- ited to TLR2 and TLR4. Studies have suggested that TLR2 and TLR4 can regulate the pathogenesis of diabetes and DN via mediating metabolic inflammatory responses.
出处
《医学综述》
2014年第4期594-596,共3页
Medical Recapitulate
基金
国家973计划项目(2011CBA01003)
关键词
TOLL样受体
糖尿病
糖尿病肾病
炎症
Toll-like receptors
Diabetes meflitus
Diabetic nepbropathy
Inflammation
