摘要
目的:探讨骨形态发生蛋白(BMP-7)在前列腺癌组织中的表达及其与临床分期之间的关系。方法:应用免疫印迹法检测30例前列腺癌患者及30例前列腺良性增生患者前列腺组织中BMP-7的表达情况。结果:前列腺癌组织中BMP-7的表达显著高于前列腺良性增生组织,且BMP-7的表达随前列腺癌的临床分期、Gleason分级增高而增加。结论:BMP-7在前列腺癌中的表达明显增高,其表达量与临床分期相关,前列腺癌组织中BMP-7的表达增高提示预后不佳。
Objective： To evaluate the relationship between the clinical stages and the expression of BMP-7 in prostate cancer （PCa） tissue. Methods： Western blot was used to detect the expression of BMP-7 in 30 PCa tissues and 30 benign prostatic hyperplasia （BPH） tissues. Results： Expression of BMP-7 was significantly higher in the PCa group than in the BPH group. The expression of BMP-7 was increasing in PCa group, especially with increasing clinic stage and Gleason score. Conclusion： BMP-7 expression in prostate carci- noma was significantly higher, it related with clinical staging of prostate cancer, the increased expression ofBMP-Tprompts a poor prog- nosis.
出处
《现代生物医学进展》
CAS
2012年第24期4679-4681,4653,共4页
Progress in Modern Biomedicine
基金
深圳市卫生局课题资助项目(YS2010129)
关键词
前列腺癌
骨转移
骨形态发生蛋白
转化生长因子Β
Prostate cancer
Bone metastasis
Bone morphogenetic proteins
Transforming growth factor-β
