摘要
目的观察β2微球蛋白在内分泌治疗前列腺癌根治术后患者体内表达情况及其与患者预后关系。方法选取我院行前列腺根治术联合内分泌治疗病例30例,术后3周服用氟他胺(250mg,3次/天)。分别在治疗前、治疗后3月、6月、12月收集患者血清,采用放射免疫法检测血清β2微球蛋白的表达。分析患者β2微球蛋白表达水平与患者Gleason评分以及PSA的关系。结果治疗后β2微球蛋白以及PSA水平均显著降低,差异有统计学意义(P<0.05)。Pearson相关性分析显示,β2微球蛋白以及PSA水平有相关性(r1=0.693,r2=0.627,P<0.05),Gleason评分与β2微球蛋白以及PSA表达水平呈正相关(r=0.857,P<0.05;r=0.793,P<0.05)。结论血清β2微球蛋白是诊断以及检测肿瘤治疗预后的有效指标,与PSA协同观察可以提高临床诊断以及治疗水平。
Objective To explore the relationship between the expression of of β-2-Microglobulin and prog- nosis in hormonal therapy treated patients with prostate cancer after the radical prostatectomy. Methods 30 pa- tients with prostate cancer treated with combined therapy of radical prostatectomy and flutamide （250 rag, Tid）. The senma of past-operation at 3, 6, 12 months were collected for the evaluation of β-2-Microglobulin. the relationship between the expression of of β-2-Microglobtdin and Gleason score and PSA expression level. Results Both the expression of β-2-Microglobulin and PSA were decreased significantly （P〈0.05）. The β-2-Microglobulin showed significantly positive related with PSA （r1=0.693, r2-0.627, P〈0.05）. The Gleason score is positive related with β-2-Microglobulin （r=0.857, P〈0.05; 1=0.793, P〈0.05）. Conclusion The expression level of β-2-Microglobulin has a close relation with the effect of the therapy for the prostate cancer.
出处
《肿瘤药学》
CAS
2011年第5期444-446,共3页
Anti-Tumor Pharmacy
关键词
Β2微球蛋白
内分泌治疗
前列腺癌
预后
β-2-Microglobulin, Hormonal therapy, Prostate cancer, Prognosis
