特利加压素比较施他宁治疗急性食管静脉曲张破裂出血被引量：8

Terlipressin vs.Stilamin for the treatment of acute bleeding from esophageal varices

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摘要目的　比较特利加压素和施他宁治疗肝硬化患者急性食管静脉曲张破裂出血的疗效和安全性。方法　特利加压素治疗组 41例 ,静推 2mg后 ,每 4h静推 1mg ;施他宁治疗组 43例 ,静注 2 5 0 μg后 ,每 1h 2 5 0 μg连续静滴。观察两种药物的止血率、再出血率、死亡率和副作用。结果　特利加压素组治疗有效率 ( 80 5 % )类似于施他宁组 ( 83 7% ) ;两组再出血率分别为 19 5 %和 2 3 3 % (P >0 .0 5 ) ,死亡率分别为 12 2 %和 16 3 % (P >0 .0 5 )。特利加压素组副作用发生率为 7 3 % ,施他宁组无明显副作用。 Aim To compare the efficacy and safety of terlipressin and stilamin for the treatment of acute variceal bleeding in cirrhotic patients.Method Of 84 patients with acute variceal bleeding,41 were choosen randomly to be given terlipressin (2mg and then 1mg/4hr by intravenous injection). The remaining were given stilamin(250μg by intravenous injection and then continuous infusion of 250 μg/h).Results Success of therapy in terlipressin group(80.5%)was similar to that in stilamin group(83.7%).The rates of repeated bleeding of the two groups were 19.5% and 23.3% respectively(P>0.05).No differences were observed in the mortality rates of the two groups(12.2% vs.16.3%).Side effects occurred in 7.3% of the patients treated with terlipressin;there were no obvious side effects in the stilamin group.Conclusion Terlipressin and stilamin are effective as first-line for the treatment of acute variceal bleeding in cirrhotic patients.

作者刘诗许军英侯晓华易粹琼

机构地区同济医科大学附属协和医院消化内科

出处《胃肠病学和肝病学杂志》 CAS 2000年第1期60-62,共3页 Chinese Journal of Gastroenterology and Hepatology

关键词特利加压素施他宁食管静脉曲张出血治疗 Terlipressin Stilamin Esophageal varices

分类号 R571.305 [医药卫生—消化系统]

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