摘要
目的 通过对一组急性HGV感染患者的肝组织病理和临床资料分析 ,探讨庚型肝炎病毒感染的致病性。方法 采用免疫组织化学技术对 5 9例不明原因急性肝炎患者的肝组织 ,进行乙、丙和庚型肝炎病毒抗原检测 ,部分病例经原位杂交证实。结果 HGVNS5抗原的检出率为 ( 5 7 6% ,3 4 /5 9) ,其中 2 0例肝组织中HBsAg和 /或HCVNS3Ag同时阳性 (HGV合并感染组 ) ,HGV阳性信号主要位于肝细胞浆内。HGV单纯感染病例与HGV重叠感染组相比 ,无论在病理改变或生化指标方面均无显著性差别。结论 HGV是一种嗜肝病毒 。
Aim To investigate the pathogenicity of HGV infection.Methods Fifty nine cases of liver biopsies from patients with acute hepatitis of unknown etiology were examined for HBsAg and HCV NS3Ag as well as HGV NS5Ag by immunohistochemical technique and partly identified by in situ hybridization.Results HGV NS5Ag was detected in 34 out of 59 cases, including 20 cases with positive HBsAg and or HCV NS3Ag simultaneously (the HGV coinfected group).The positive signals of HGV antigen were located mainly in cytoplasm of hepatocytes. There were no differences between the group of the HGV infection alone(14 cases) and the HGV coinfected group (P>005).Conclusion HGV is a hepatotropic virus and its infection could cause acute hepatitis.
出处
《胃肠病学和肝病学杂志》
CAS
2000年第1期42-44,共3页
Chinese Journal of Gastroenterology and Hepatology
