摘要
目的探讨糖尿病肾病(DN)患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和血管内皮生长因子(VEGF)水平的变化。方法将63例2型糖尿病(T2DM)患者根据是否并发肾脏损害分为T2DM组35例和DN组28例,另选同期体检健康者30人为正常对照组,检测3组血清CRP、TNF-α和VEGF水平,并进行比较。结果 T2DM组和DN组患者血清CRP、TNF-α和VEGF水平显著高于正常对照组,差异有统计学意义(P<0.05);DN组患者血清CRP、TNF-α和VEGF水平显著高于T2DM组,差异有统计学意义(P<0.05)。结论 CRP、TNF-α和VEGF可能与DN的发生和发展有关。
Objective To explore the change of the levels of serum C reactive protein（CRP）,tumor necrosis factor-α（TNF-α）and vascular endothelial growth factor（VEGF） in patients with diabetic nephropathy（DN）.Methods Sixty-three patients with type 2 diabetes mellitus（T2DM） were divided into T2DM group（n=35） and DN group（n=28） according to whether complicated with renal damage,and thirty healthy people were chose as normal control group.The levels of serum CRP,TNF-α and VEGF were detected and compared in three groups.Results The levels of serum CRP,TNF-α and VEGF in T2DM group and DN group were significantly higher than those in normal control group,the differences were statistically significant（P〈0.05）.The levels of serum CRP,TNF-α and VEGF in DN group were significantly higher than those in T2DM group,the differences were statistically significant（P〈0.05）.Conclusion CRP,TNF-α and VEGF may be related to the occurrence and development of DN.
出处
《新乡医学院学报》
CAS
2012年第9期678-679,共2页
Journal of Xinxiang Medical University
关键词
糖尿病肾病
C反应蛋白
肿瘤坏死因子Α
血管内皮生长因子
diabetic nephropathy
C reactive protein
tumor necrosis factor-α
vascular endothelial growth factor
