摘要
慢波睡眠(SWS)是最重要的睡眠成分。近年来的研究揭示:腹外侧视前区结节乳头核(VLPOTMN)可能是睡眠觉醒的中枢发生部位。基底前脑吻端前列腺素D2(PGD2)敏感性睡眠促进区(PGD2SPZ)参与睡眠的调控。PGD2延长SWS;前列腺素E2(PGE2)延长觉醒,抑制SWS和快动眼睡眠(REMS)。SWS与下丘脑垂体肾上腺皮质轴的活动呈负相关,与生长激素的分泌呈正相关。褪黑素(melatonin)对SWS的影响与其降低体温的效应有关。白细胞介素1(IL1)促进SWS的作用可能通过PGD2介导。5HT参与肿瘤坏死因子延长SWS的作用。睡眠觉醒机制的研究进展提示,开发新型选择性延长SWS的药物,可以从以下几方面入手:PGD2激动剂;免疫增强剂或免疫调节剂;影响5HT系统的药物;褪黑素及生长激素等睡眠的生理性调节物质等。
SWS is the most important component of sleep. (1) VLPO TMN seems to generate sleep and wakefulness. The rostral basal forebrain, which was defined as PGD 2 SPZ, may be involved in regulation of sleep. (2) PGD 2 promotes sleep, especially SWS, while PGE 2 prolongs wakefulness and depresses both SWS and REMS. (3) During SWS the activation of hypothalamus pituitary adrenocortic axis is inhibited, while the release of growth hormone is accelerated. The soporific effects of melatonin may be attributed to its hypothermic effects. (4) Interleukin 1 prolongs sleep, especially SWS, which seems to be mediated by PGD 2. Tumor necrosis factor (TFN) may promote SWS through 5 HT and its receptor. Therefore, the development of new hypnotics, which selectively prolong SWS, might follow the following ways: PGD 2 and chemicals which act like PGD 2; immuno regulators; substances with effects on 5 HT receptors; hormone, such as melatonin and growth hormone, which play roles in the physiological regulation on sleep wakefulness.
出处
《生理科学进展》
CAS
CSCD
北大核心
2000年第1期30-34,共5页
Progress in Physiological Sciences
