摘要
通过建立失眠大鼠模型 ,予保神开郁冲剂高、低剂量组及各对照组灌胃治疗 ,利用荧光分光光度法检测大鼠中脑、桥脑、延脑等 5-羟色胺 (5 - HT) 、5-羟吲哚乙酸 (5 - HIAA) 、去甲肾上腺素 (NA) 、多巴胺(DA) 含量的变化 ,分析保神开郁冲剂增加深睡 ,提高睡眠质量的机理。结果显示 ,保神开郁冲剂高、低剂量组能够使 5- HT含量增加 ,NA、DA的含量降低 ,并与其它对照组呈显著性差异(P<0 .0 5 ) ,保神开郁冲剂增加深睡的内在机理是影响脑内 5- HT、NA、DA的含量而作用于睡眠—觉醒机制的。
The experiment,forming the rat model of asomnia,treated with Baoshenkaiyuchongji at high dose,low dose and other Control medicine by means of purfusion(IG),analysising the variation of the content of 5-HT,5-HIAA,NA,DA of midbrain,pons,medulla ablongata by spectrophofluorometric,was designed to make further inguiry into the mechanism of Baoshenkaiyuchongji increasing deep sleep and improving sleep.Results:In the Baoshenkaiyuchongji group at HD or LD ,the content of 5-HT increased but the content of NA and DA decreased,compared with other control groups,difference was significant(P<0.05).Conclusion:The intrinsic mechanism of Baoshenkaiyuchongji increasing deep sleep probably lied in which it acted on sleep awakening mechanism by affecting the content of 5-HT,NA,DA of the brain.\;
出处
《辽宁中医杂志》
CAS
北大核心
2000年第2期92-94,共3页
Liaoning Journal of Traditional Chinese Medicine
