摘要
目的 进一步研究病毒性乙型肝炎的发病机制 .方法 采用 APAAP技术和 EL1SA法检测 92例慢性乙型肝炎患者 T细胞亚群和血清 s IL - 2 R,TNF-α和 IL - 6水平 .结果 发现慢性乙型肝炎患者 CD4+细胞数较正常低 ,CD8+细胞和血清中 s IL- 2 R,TNF- α和 IL- 6水平明显增高 .在慢性肝炎、肝硬化患者活动期与稳定期之间 ,重型肝炎患者的肝坏死期与恢复期之间 ,血清 TNF- α和 IL- 6二项指标的差异有显著性 ,均 P<0 .0 1.结论 表明乙肝患者存着免疫调节紊乱 。
AIM To further investigate the pathogenesis of viral hepatitis B. METHODS APAAP technique and ELISA were used to detect the levels of sIL-2R, TNF-α, IL-6 in serum and T cell subsets in 92 patients suffering chronic hepatitis B. RESULTS It was found the CD4 + cells, com-pared with normal people, were low in number. CD8 + cells and levels of sIL-2R, TNF-α, IL-6 in serum were significantly increased. Between cirrhosis active and stable stages in chronic hepatitis, and between liver necrosis and recovery stages in severe hepatitis there was a significant difference in levels of serum TNF-α, IL-6 ( P <0.01). CONCLUSION It is suggested that there is disorder in immune regulation in hepatitis B patients. The abnormalities in immune regulation partly may result from cellular factors.
出处
《第四军医大学学报》
2000年第7期814-816,共3页
Journal of the Fourth Military Medical University
