摘要
目的 研究慢性病毒性肝炎患者血清IL-12水平、T细胞亚群变化及意义。 方法 分别采用双抗体夹心ELISA法与抗体致敏的红细胞花环试验法 ,对55例慢性病毒性肝炎患者血清IL -12水平及T细胞亚群进行了测定。结果 慢性病毒性肝炎患者IL-12水平、CD细胞、CD/CD比值明显低于正常对照组 ,而CD细胞则明显增高 ;HBV -DNA阳性组CD细胞、CD/CD比值明显低于HBV -DNA阴性组 ,而CD细胞则明显高于HBV -DNA阴性组 ,IL-12水平则无显著差别。结论 慢性病毒性肝炎患者存在细胞免疫功能低下 ,免疫调节功能紊乱 ,IL-12及T细胞亚群的检测对监测慢性病毒性肝炎患者不同临床类型的疾病活动 ,病毒复制 ,指导治疗都具有一定的意义。
Objective To explore the change and significance of serum I L-12levels and Tsubsets in patients with chronic viral hepatitis. Methods Serum IL-12levels and T subsets in55patients with chronic viral hepatitis were detected with double-sandwich ELISA and erythrocyte garland test respectively. Results In comparison with normal control,serum IL-12levels,CD cells and CD/CD ratio were significantly less in patients with chronic viral hepatitis,and CD cells were markedly higher.CD cells,CD/CD ratio in HBV-DNA positive group were obviously less than those in HBV-DNA negative group,and CD cells was significantly higher than than in HBV-DNA negative group.There was no significant difˉference between HBV-DNA positive group and HBV-DNA negative group. Conclusion There was immunology disorder,deficiency.Detection of IL-12level and Tsubsets in chronic viral patients was valuable to some extent in monitoring the status of disease,viral replication,and directing therapy.
出处
《浙江临床医学》
2004年第12期1037-1038,共2页
Zhejiang Clinical Medical Journal
