摘要
目的探究Annexin II、尿激酶型纤溶酶原激活剂（uPA）在甲状腺癌发生发展和淋巴结转移中的作用。方法应用免疫组织化学法检测AnnexinII、uPA蛋白在35例甲状腺乳头状癌组织、10例甲状腺腺瘤组织、16例结节性甲状腺肿组织、7例甲状腺正常组织中的表达。结果Annexin II、uPA蛋白在甲状腺乳头状癌组织中的表达较正常、结节性甲状腺肿和腺瘤组织中的表达显著增高（P〈0．05），且2者在癌组织中的表达呈正相关（P〈0．05）。Annexin II蛋白的表达与肿瘤大小和淋巴结转移有关，uPA蛋白的表达只与淋巴结转移有关。结论Annexin II、uPA蛋白参与了甲状腺乳头状癌的发生发展；并在甲状腺乳头状癌淋巴结转移中发挥促进作用。
Objective To explore the role of Annexin II and urokinase-type plasminogen activator（uPA） proteins in the development and lymph node metastasis of thyroid cancer. Methods Immunohistoehemistry was used to detect the expression of Annexin II and uPA proteins in 35 cases of papillary thyroid cancer tissues, 10 cases of thyroid adenoma tissues, 16 cases of nodular goiter tissues and 7 cases of normal thyroid tissues. Results The positive expression rate of Annexin II and uPA protein was significantly higher in papillary thyroid cancer than in normal thyroid tissues, nodular goiter tissues and thyroid adenoma tissues（ P 〈 0. 05 ）. The expression of Annexin II and uPA protein was positively correlated in papillary thyroid cancer tissues（P 〈0. 05）. The expression of Annexin II protein in thyroid cancer tissues was associated with tumor size and lymph node metastasis while the expression of uPA protein was only related to lymph node metastasis. Conclusions Annexin II and uPA proteins are involved in the occurrence and development of papillary thyroid cancer. They also play a facilitating role in lymph node metastasis of papillary thyroid cancer.
出处
《中华内分泌外科杂志》
CAS
2012年第4期217-220,共4页
Chinese Journal of Endocrine Surgery
基金
基金项目：河南省卫生科技创新人才工程基金（豫卫科[2010152号）
