摘要
本研究对比观察了赤芍和硝苯啶对兔实验性动脉粥样硬化(AS)的彤响。结果表明,两种药物均使高脂血症引起的 TXA_2/PGI_2比值改变趋向平衡,降低血浆 LPO、动脉壁脂质、钙和磷脂及主动脉斑块面积。赤芍明显强于硝苯啶。提示两种药物通过影响钙代谢调节 TXA_2/PGI_2平衡是其抗 AS 主要作用机理之一。赤芍可以作为防治 AS 的一种新药物用于临床。
The authors examined the influences of nifedipine and Paeonia lactiflora(PL)on plasma LPO, TXB_2 and 6-keto-PGF_(1α) in cholesterol-fed rabbits.In this study,oral administration of nifedipine(15 mg/kg per day)and PL(0.5 g/kg per day)with 2% cholesterol diet for 15 weeks caused 60.75% and 74.24% reduction in the lesion area of aorta respectively.The levels of plasma LPO,TXB_z, cholesterol,phospholipid and calcium of the intimalmedia of the aorta in the treated groups were significantly lower than those in the control group,but the level of 6-keto-PGF_(1α) in the treated groups was significantly higher.The durations of TXB_2 elevation and 6-keto-PGF_(1α) reduction were delayed.The ratio of TXB_2/6-keto-PGF_(1α) tended to balance.The ratio of TXB_2/6-keto-PGF_(1α) was significantly positive correlation with the percentage of lesion area of the aorta.It is demonstrated that calcium metabolism plays an important role in thromboxane,prostaglandin,and LPO synthesis. In conclusion,the inhibition of LPO production and the regulation of TXA_2-PGI_2 balance may be one of the mechanisms of anti-atherogenesis of calcium antagonists and PL.
