摘要
目的研究黑老虎(Kadsura coccinea)的化学成分。方法采用硅胶柱色谱、凝胶柱色谱、反相ODS柱色谱进行分离,根据理化性质和波谱数据鉴定化合物的结构。结果从黑老虎根中分离得到14个化合物,分别鉴定为isovaleroyl-binankadsurin A(1)、kadsuralignan J(2)、acetyl-binankadsurin A(3)、五味子甲素(4)、去氢二异丁香酚(5)、内消旋二氢愈创木脂酸(6)、豆甾-4-烯-3-酮(7)、没食子酸(8)、水杨酸(9)、2-甲氧基苯甲酸(10)、邻苯二甲酸二丁酯(11)、5-羟甲基糠醛(12)、天师酸(13)、α-棕榈酸甘油酯(14)。结论化合物5、7～11、13、14为首次从该属植物中分离得到,化合物1和6为首次从该植物中分离得到。
The roots of Kadsura coccinea has been widely used as a folk medicine to treat gastric and duodenal ulcer,chronic gastritis,acute gastroenteritis,rheumatic arthritic,dysmenorrheal,etc.The constituents of the roots of K.coccinea were isolated by silica gel,ODS,sephadex LH-20 column chromatography,and their structures were elucidated by the spectroscopic analysis.Fourteen compounds were obtained and identified as isovaleroyl-binankadsurin A（1）,kadsuralignan J（2）,acetyl-binankadsurin A（3）,deoxyschizandrin（4）,dehydrodiisoeugenol（5）,meso-dihydroguaiaretic acid（6）,stigmast-4-en-3-one（7）,gallic acid（8）,salicylic acid（9）,2-methoxy benzoic acid（10）,dibutylphthalate（11）,5-hydromethyl furaldehyde（12）,tianshic acid（13）,α-glyceryl palmitate（14）.Compounds 5,7-11,13 and 14 were isolated from the genus Kadsura for the first time.Compounds 1 and 6 were isolated from Kadsura coccinea for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2012年第4期305-309,共5页
Chinese Journal of Medicinal Chemistry
关键词
黑老虎根
化学成分
结构鉴定
Kadsura coccinea
chemical constituent
structural identification
