摘要
在用活血化瘀方药和益气化瘀方药防治不均称型胎儿宫内发育迟缓(IUGR)原实验研究的基础上进一步探讨了其作用机制,证明活血化瘀方药改善不均称型 IUGR 与其维持母血红细胞形态,增加红细胞变形能力,降低全血粘度,防止血液浓缩从而改善胎盘循环有关。
The purpose of this study was to observe the therapeutical and preventive effect of the compound prescriptions of Huoxue Huayu(promoting blood circulation to remove stasis,PBCRS) and Yiqi Huoxue(益气活血,replenishing Qi(气)to remove stasis,RQRS)on experimental intrauter- ine growth retardation(IUGR)caused by passive smoking during pregnancy in rats.The fetal average birth weight and the erythrocyte deformability were found to be significantly reduced in the smoke-exposed group compared with the control group.However,there was a significant increase of blood viscosity(at both shear rates),Hb,Ht,MCV,MCH levels and the erythrocyte fragility in the smoke-exposed group in comparison with the control group.After the mother-rats were given PBCRS and RQRS prescriptions during gestion,the fetal average birth weight and erythrocyte deformability were markedly increased.The blood viscosity,Hb,Ht,MCV,MCH levels and erythrocyte fragility of pregnant rats were decreased.No differences were found in the control group and the two treated groups.The electronic microscope observation of erythrocyte shape shows there were some protrusions on the surface of red cells in the smoke-exposed group.The protrusions were significantly reduced in the two treated groups,which was similar to the control group.The erythrocyte deformability,the blood viscosity,Hb.Ht,MCV,MCH levels indicate that there was significant correlation between them and the fetal average birth weight respeetively.This study indicates that blood stasis is one of the pathogenetic mechanisms of asymmetrical IUGR and that the PBCRS recipe could improve intrauterine growth environment of fetal which could treat and prevent IUGR in obstetrics.
出处
《中西医结合杂志》
CAS
CSCD
北大核心
1990年第3期157-159,共3页
