摘要
目的探讨熊胆粉对高脂饮食豚鼠肝脂肪变性的预防及其作用机理。 方法 80只豚鼠随机分 4组 ,为空白组、高脂组、熊胆粉组、熊去氧胆酸 (UDCA)组 ,分别检测胆汁生化和肝脏病理。 结果熊胆粉能降低胆汁胆固醇浓度 ,提高胆汁胆汁酸浓度 ,缓解肝脂肪变性。 结论熊胆粉能有效缓解高脂高热量饮食引起的肝脂肪变性 ,且无明显的不良反应。
Objective To determine whether bear bile could prevent fatty degeneration of liver cells caused by high fat diet and the mechanism. Methods Eighty guinea pigs randomly sepe rated into 4 groups: control group, high fat diet group, high fat diet plus bear bile group and high fat diet plus ursodeoxycholic acid(UDCA) group. Two months later, the bile biochemistry and pathologic changes of the liver were investigated. Results Bear bile could decrease the concentration of cholesterol in bile, raise the concentration of bile acid in bile and relieve fatty degeneration of liver. Conclusion Bear bile could relieve fatty degeneration of liver caused by high fat diet without any side effects.
出处
《上海第二医科大学学报》
CSCD
2000年第4期313-314,共2页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
熊胆粉
高脂饮食
预防
肝脂肪变性
bear bile\ \ high fat diet\ \ prevent\ \ guinea pig\ \ fatty degeneration of liver
