摘要
目的探讨文拉法辛联合小剂量奥氮平治疗抑郁症的疗效和安全性。方法对60例抑郁症患者,随机分为单用组(单用文拉法辛)和合用组(文拉法辛合用奥氮平),疗程8周。采用汉密尔顿抑郁量表(HAM D)和副反应量表(TESS)评定疗效及不良反应。结果①两组治疗后HAM D评分均较治疗前明显下降(P均<0.01);两组间比较,合用组起效快,治疗第1、2、4周末,合用组HAM D评分显著低于单用组(P均<0.05);②合用组疗效优于单用组,但在第8周末疗效差异无统计学意义(t=1.253,P=0.153);③两组不良反应比较无明显差异(t=0.668,P=0.247)。结论文拉法辛合用小剂量奥氮平治疗抑郁症起效快,可增加疗效,安全性好。
Objective To study the efficacy and safety of venlafaxine combined with small-dose olanzapine in the treatment of depression.Methods A total of 60 patients with depression were randomly assigned to two groups：Combined group,venlafaxine with olanzapine,and control group,venlafaxine only,for 8 weeks.Hamilton Rating Scale for Depression（HAMD）and Treatment Emergent Symptom Scale（TESS）were used to evaluate clinical efficacy and safety.Results ①The score of HAMD reduced significantly after treatment in two groups（both P〈0.01）,with significantly lower scores of HAMD in combined group in 1st,2nd and 4th weeks treatment when compared to those in control group（both P〈0.05）.②No significant difference was found in the curative effects between two groups at the end of 8 weeks（t=1.253,P=0.153）.③There was no significant difference in adverse effects between two groups（t=0.668,P=0.247）.Conclusion Venlafaxine combined with olanzapine in the treatment of depression may augment the treatment effect and has a good safety.
出处
《中国健康心理学杂志》
2012年第8期1139-1140,共2页
China Journal of Health Psychology
关键词
文拉法辛
奥氮平
抑郁症
疗效
Venlafaxine； Olanzapine； Depression； Efficacy
