帕罗西汀联合小剂量喹硫平治疗抑郁症躯体症状25例疗效观察被引量：2

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摘要目的:观察并分析帕罗西汀联合小剂量喹硫平对抑郁症躯体症状的临床治疗效果,探讨喹硫平在应用帕罗西汀治疗抑郁症躯体症状的增效作用及安全性。方法随机选取我院在2010年12月~2012年12月收治的伴有躯体症状的抑郁症患者50例,随机平均分为两组,帕罗西汀联合小剂量喹硫平组(联合组)与帕罗西汀未联合小剂量喹硫平组(对照组),每组25例。联合组患者从入院起给予每天饭后口服帕罗西汀10mg,同时联合每天口服小剂量喹硫平50mg。对照组患者只给予每天饭后口服帕罗西汀10mg(两组患者服用帕罗西汀的时间一致),随着治疗的进行,适当增加药物的用量直到达到患者所需的剂量,两组患者的均给予连续6w的治疗。记录所有患者在治疗前和治疗后1w,2w,4w和6w进行的汉密尔顿抑郁量表(HAMD)的评分和焦虑/躯体化因子评分,同时记录所有患者在治疗后1w,2w,4w和6w采用副反应量表(TESS)所得的药物副反应评分,进而分析帕罗西汀联合小剂量喹硫平治疗抑郁症躯体症状临床疗效。结果联合组总有效率为86%,对照组总有效率为76%。联合组的治愈率显著高于对照组(P<0.05)。两组治疗后HAMD和躯体/症状因子评分均较治疗前低,联合组从第2w末开始HAMD和躯体/症状因子评分明显较对照组低,并且差异有统计学意义(P<0.05)。两组TESS评分无明显差异,并且两组患者的副反应均较轻。结论帕罗西汀联合小剂量喹硫平对抑郁症患者的躯体症状的疗效显著,是治疗伴有躯体症状的抑郁症的一种安全有效的方法。

作者朱宇华

机构地区湖南郴州市精神病医院八病区

出处《医学信息（医学与计算机应用）》 2014年第16期125-125,共1页 Medical Information

关键词帕罗西汀小剂量喹硫平抑郁症躯体症状

分类号 R74 [医药卫生—神经病学与精神病学]

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