摘要
目的检测癫痫患儿脑组织葡萄糖代谢情况,探讨其在癫痫患儿诊疗中的意义。方法选择癫痫患儿78例为观察组,健康儿童60例为对照组,利用正电子发射体层摄影术(positron emission tomography,PET)显像检测对比癫痫灶脑细胞葡萄糖代谢情况。结果①观察组78例癫痫患儿脑PET检查显像脑组织葡萄糖代谢异常68例,异常检出率为87.18%。其中低代谢异常6I例,高代谢异常7例,明显高于正常对照组异常检出率0,差异有统计学意义(P<0.05)。脑组织葡萄糖代谢异常68例中,全身强直-阵挛发作19例,主要异常脑区为额时和颞叶;失神发作26例,主要异常脑区为额叶、颞叶和顶叶;单纯部分性发作15例,主要异常脑区为额叶、颞叶和顶叶;复杂部分性发作5例,主要异常脑区为颞叶;自主神经性发作3例,主要异常为大脑皮层弥漫性异常。②PET检出率为87.18%,脑电图(electroencep halogram,EEG)检出率为88.46%,磁共振成像(magneticresonance imaging,MRI)检出率最低为83.33%,但3种辅助检查方法的检出率比较差异均无统计学意义(P>0.05)。结论对癫痫患儿通过^(18)氟-脱氧葡萄糖示踪PET脑显像进行脑组织葡萄糖代谢检测结合EEG、MRI等辅助检查,既可以发现脑电生理和脑组织结构的异常改变,又可以检测脑组织葡萄糖代谢异常,可为临床提供有价值的诊疗依据。
Objective To test brain tissue glucose metabolism for epilepsy children, and discuss the meaning of diagnosis and treatment to epilepsy children. Methods Seventy - eight cases of epilepsy children were selected into the observation group, 60 healthy children were selected into the control group, epileptic foci of brain cell glucose metabolism was detected by using positron emission tomography （PET）. Results ① There were 68 cases of brain tissue glucose metabolism abnormality in the observation group of 78 cases of epileptics children,with 61 cases of lower metabolic abnormalities and 7 cases of high metabolic abnormalities. The abnormal detection rate was 87.18%, much higher than normal control group （ 0% ）, with a significant defference （ P 〈 0. 05 ）. In 68 cases of brain tissue glucose metabolism abnormality, there were 19 cases of generalized tonic -clonic seizure ,the main abnormal brain regions were the frontal and temporal lobe ;26 cases of epilepsy absence, the main abnormal brain regions were the frontal, parietal lobe and temporal lobe; 15 cases of simple partial seizure, the main abnormal brain regions were the frontal, parietal lobe and temporal lobe ; 5 cases of complex partial seizure, the main abnormal brain regions were temporal lobe ; 3 cases of autonomic nerve seizure, the main abnormality was the cerebral cortex diffuse abnormalities. ②The PET detection rate was 87. 18%, the deteetion rate of EEG was 88.46% and the MRI was 83.33% ,but the comparative differences of three kinds of auxiliary examination method were not significant （ P 〉 0. 05 ）. Conclusion Testing brain tissue glucose metabolism for epilepsy children by 18fluorine- deoxidizing glucose（ 18F- FDG） traced PET combined with EEG and MRI, can find abnormal changes of brain electrical physiology and brain structure, and can detect brain tissue glucose metabolic abnormalities so as to provide valuable basis for clinical diagnosis and treatment.
出处
《河北医科大学学报》
CAS
2012年第8期884-886,共3页
Journal of Hebei Medical University
关键词
癫痫
葡萄糖
诊断
epilepsy
glucose
diagnosis
