摘要
目的探讨3′-脱氧-3′-18F-氟代胸苷(18F-FLT)PET/CT显像在恶性肿瘤诊断中的应用价值。方法对31例恶性肿瘤患者行18F-FLT PET/CT显像,分析18F-FLT PET/CT显像中病灶感兴趣区(ROI)最大标准摄取值(SUVmax)和平均标准摄取值(SUVmean)与肿瘤类型、病理类型和分期的关系。结果 18F-FLT PET/CT显像图像质量好,病灶显影清晰。31例共发现100处病灶18F-FLT高摄取,SUVmax为(5.20±2.79),SUVmean为(4.35±2.38);其中,肺癌患者淋巴结转移4处,SUVmax为(2.29±1.54),SUVmean为(1.72±1.09),较鼻咽癌组低(P<0.05);鼻咽癌不同病理类型间SUV值差异无统计学意义(P>0.05)。结论 18F-FLT PET/CT显像能清晰显示鼻咽癌、肺癌、淋巴瘤、喉癌、肾盂癌原发病灶及转移病灶,有临床应用价值。
Objective to evaluate the usefulness of 18F-FLT PET/CT fusion imaging in different carcinomas.Methods Thirty-one patients with histologically proven carcinoma underwent whole-body 18F-FLT PET/CT scan.The maximum standard uptake value（SUVmax） and nean SUV（SUVmean） for 18F-FLT were calculated.Results In all patients,18F-FLT uptake could be detected in the primary tumor or metastasis site.The SUVmax and SUVmean for 18F-FLT in 100 lesions of 31 patients with carcinoma were （5.20±2.79） and（4.35±2.38）,respectively.The SUVmax and SUVmean of metastasis lesions of lung cancer were（2.29±1.54） and（1.72±1.09）,which were lower than those of nasopharyngeal carcinoma lesions（P0.05）.Conclusion 18F-FLT PET/CT imaging provides an useful supplementary information that assists the diagnosis of carcinomas.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第9期1056-1058,共3页
Jiangsu Medical Journal
基金
苏州市社会发展计划项目(SS08031SS0807)
