4[9]Loo TW,Clarke DM.Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiesulfonate analog of verupamil,MTS-verapamil[J].JBiol Chem,2001.276(18):14972-14979.
5[10]Loo TW,Bartlett MC,Clarke DM.Substrate-induced conforulational changes in the tmusmembrane segments of human P-glycoprotein.Direct evidence for the substrate-induced fit mechanismfor drug binding[J].J Biol Chem,2003,278(16):13603-13606.
6[11]Merteus-Talcott SU,De Castro WV,Manthey JA,et al.Polymethoxylated flavones and other phenofic derivates from citrus in their inhibitory effects on P-glyeoprutein-mediated transport of talinolol in Caco-2 cells[J].J Agric Food Chem.2007,55(7):2563 2568.
7[12]Rand I,Terreux R,Richomme P,et al.Structure-activity relafionship of natural and synthetic coumarins inhibiting the multidrag transporter P-glycopmtein[J].Bioorg Med Chem,2006,14(20):6979-6987.
8[13]Shitan N,Tanaka M,Terai K,et al.Human MDRI and MRP1 recognize berberine a8 their transport substmte[J].Biosci Bio-technol Biochem,2007,71(1):242-245.
9[14]Hugger ED,Novak BL,Burton PS,et al.A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro[J].J Pharm Sci,2002,91(9):1991-2002.
10[15]Hugger ED,Audus KL,Borehardt RT,et al.Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayem[J].J Pharm Sci,2002,91(9):1980-1990.
