摘要
目的探讨单纯疱疹病毒感染对老年冠心病急性心肌梗死血液流变特性的影响。方法选择医院2010年6月-2011年6月老年急性心肌梗死46例患者设为观察组,50例陈旧性心肌梗死患者设为对照A组,50例冠脉造影正常者设为对照B组,观察3组单纯疱疹病毒阳性率及血液流变学指标。结果观察组HSV-1IgG阳性34例,阳性率为73.91%,HSV-1IgM阳性32例,阳性率为69.57%,HSV-1DNA阳性33例,阳性率为71.74%,观察组阳性率明显高于对照B组,略高于对照A组,组间比较,差异有统计学意义(P<0.05);观察组阳性患者HSV-1IgG为(108.40±44.20)KU/L、低切全血黏度为(9.23±1.56)mPas、高切全血黏度为(4.61±0.52)mPas、血浆黏度(1.81±0.23)mPas、红细胞聚集指数(2.25±0.17)、红细胞积压(48.39±6.74)%;各指标均高于对照A、B组阳性病例,组间比较,差异有统计学意义(P<0.05)。结论单纯疱疹感染对老年冠心病急性心肌梗死有明显的影响,与血液流变特性指标有一定相关性。
OBJECTIVE To investigate the effect of herpes simplex virus infection on the hemorheological characteristics of the elderly patients with acute myocardial infarction. METHODS A total of 46 elderly patients with acute myocardial infarction who enrolled in hospital from Jun 2010 to Jun 2011 were assigned to the observation group, 50 patients with remote myocardial infarction were chosen as the control group A, and 50 cases with normal coronary angiography were chosen as the control group B, the herpes simplex virus-positive cases and the indicators of hemorheology for the three groups were observed. RESULTS In the observation group, there were 34 cases with positive HSV-1 lgG, accounting for 73.91%, 32 （69. 57%）cases with positive HSV-1 IgM, 33 （71.74%）cases with positive HSV-1 DNA; the positive rate was significantly higher in the observation group than that in the control group B, slightly higher than in the control group A, the difference was statistically significant（P〈0.05） ;in the observation group, the HSV-1 IgG value of the positive cases was （108.4 ±44.2） KU/L, low-shear whole blood viscosity （9.23 ± 1.56） mPas, high shear whole blood viscosity （4.61± 0. 52） mPas, plasma viscosity （1.81±0.23）mPas, erythrocyte aggregation index （2.25±0.17）, red blood cell backlog （48.39 ±6.74）%; all the indexes were higher than those of the positive cases in the control group A and group B, the differences were statistically significant （P 〈0. 05）; CONCLUSION Herpes simplex infection has a significant impact on the elderly patients with acute myocardial infarction, it has certain relevance with hemorheological characteristic indicators.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第16期3511-3513,共3页
Chinese Journal of Nosocomiology
关键词
单纯疱疹病毒
冠心病
急性心肌梗死
血液流变特性
老年
Herpes simplex virus
Coronary heart disease
Acute myocardial infarction~ Hemorheological characteristics
Elderly
