摘要
目的 探讨表皮生长因子受体 (EGFR)表达与大肠肿瘤的发生、细胞增殖的关系及其临床病理学意义。方法 应用免疫组化技术 (ABC法 ) ,检测 15例正常大肠粘膜、2 8例癌旁粘膜、11例大肠腺瘤、72例大肠癌中EGFR表达和增殖细胞核抗原 (PCNA)指数。结果 ①EGFR在正常粘膜、癌旁粘膜、大肠腺瘤及大肠癌中的阳性率分别为 6 .7%、14.3%、45 .5 %及 41.9% ,大肠癌的阳性率明显高于正常粘膜和癌旁粘膜 (P <0 .0 1) ;②EGFR的表达与PCNA指数增高无明显关系 (P >0 .0 5 ) ;③EGFR的表达与癌的生长方式、浸润深度、组织学类型、淋巴结转移、Dukes分期及预后之间无肯定关系 (P >0 .0 5 )。结论 EGFR表达在大肠肿瘤的发生中起一定作用 。
Objective To investigate the correlation of epidermal growth factor receptor (EGFR) to the genesis of colorectal cancer and cell proliferation and its clinicopathological significance.?Methods The expression of EGFR and proliferating cell nuclear antigen (PCNA) was analyzed by ABC immunohistochemical method in 15 cases of normal colorectal epithelium, 28 cases of paracancerous mucosa, 11 cases of colorectal adenomas and 72 cases of colorectal carcinomas.?Results ① The positive rates of EGFR were 6.7%, 14.3%, 45.5% and 41.9% in normal colorectal epithelium, paracancerous mucosa, colorectal adenomas and colorectal carcinomas respectively. It was significantly higher in colorectal carcinomas than in normal colorectal epithelium and paracancerous mucosa(P<0.01).②The expression of EGFR was independent of PCNA expression. ③ The expression of EGFR in colorectal cancers showed no definite relation to the manner of tumor growth, depth of infiltration, histology of the tumor, metastasis to lymph nodes, or to the clinical stage and prognosis of the cancer.?Conclusion The expression of EGFR plays a certain role in the genesis of colorectal carcinoma, but could not be regarded as an independent index indicating the malignancy and prognosis of colorectal cancer .
出处
《徐州医学院学报》
CAS
2000年第2期105-107,共3页
Acta Academiae Medicinae Xuzhou
关键词
大肠癌
免疫组织化学
EGFR
细胞增殖
colorectal carcinoma
epidermal growth factor receptor
proliferating cell nuclear antigen
immunohistochemistry
prognosis
