摘要
为了研究大肠癌表皮生长因子受体（ＥＧＦＲ）和ｐ５３蛋白表达与病理特征和预后的关系，应用免疫组化检测ＥＧＦＲ和ｐ５３在６１例大肠癌中的表达。结果提示：正常大肠粘膜未发现ＥＧＦＲ和ｐ５３阳性表达，而两者在大肠癌均有较高表达（７７．０４％和５５．７５％）。ＥＧＦＲ表达与大肠癌Ｄｕｋｅｓ分期有关（Ｐ＜０．０５）。ｐ５３表达与大肠癌分化程度及Ｄｕｋｅｓ分期有关（Ｐ＜０．０５）。大肠癌生存率随ＥＧＦＲ和ｐ５３表达增高而降低，其中两者４年生存率＞６５％表达组均明显低于＜２５％组（Ｐ＜０．０５），ＥＧＦＲ－ＬＩ和ｐ５３－ＬＩ与生存期均有明显负相关。结果表明：ＥＧＦＲ和ｐ５３表达与大肠癌的进展程度有关，该两项指标对大肠癌临床诊治和预后的评估有重要价值。
In order to study clinicopathological characteristics and prognostic significance of epidermal growth factor receptor (EGFR) and p5 3 protein expression, immunohistochemical staining was performed on paraffin-embedded sections of 61 colorectal carcinomas.The results showed EGFR and p53 positive rate was higher (77.04% & 55.75%)in colorectal carcinomas, but not in normal mucosa.EGFR expression was relate to Dukes stage(P<0.05), and p53 expression was relate to the degree of differentiation and Dukes stage(P<0.05). In the expression of EGFR and p53 among≤25% group, 25%～65%group and>65%group, the survival rate decreased with the increasing positive rate.There was a significant relation(>65%group vs≤25%group, P<0. 05) in 4-year survival rate. There was an inverse correlation between EGFR-LI and survival rate, so was p53-LI. These re sults suggest that expression of EGFR and p53 is relate to development of colorectal carcinoma, and EGFR and p53 play an important role in clinic diagnosis,treatment and prognostic evaluation.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1996年第3期206-209,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
大肠肿瘤
表皮生长因子
受体
P53蛋白
病理学
colorectal carcinoma
epidermal growth factor receptor
p53 protein
clinicopathology
prognosis
