摘要
目的:探讨血管紧张素Ⅱ_1型受体(AT1R)基因A1166/C多态性与国人原发性高血压及其合并冠心病的关系,并探讨原发性高血压的发病机制。方法:应用聚合酶链反应、限制性内切酶酶解的方法检测70例健康人和70例高血压患者,其中34例合并冠心病患者的AT1R基因型。结果:原发性高血压组的C等位基因频率13.6%,显著高于正常对照组的3.6%(P<0.005);高血压合并冠心病组的C等位基因频率13.2%,与高血压无合并症组的13.9%差别无显著性意义(P>0.05)。结论:提示AT1R基因A1166/C多态性是原发性高血压的重要遗传因素。
Objective:To identify the polymorphism of angiotensinⅡtypes 1 receptor gene in Chinese essential hypertension.Methods:This study included 70 hypertensive(involved 34 hypertensives complicated with coronary artery disease)and 70 normotensive subjects.AT1R genotyping was analyzed by polymerase chain reaction,digestion of restriction enzyme and electrophoresis.Results:The frequencies of C allele among the essential hypertension group(12.9%)were higher than those among the control group(3.6%,P<0.005).The frequencies of C allele were no difference between hypertensives complicated with coronary artery disease and hypertensives without cardiovascular or cerebrovascular disases.Conclusion:The AT1R gene A1166/C polymorphism is probably an important hereditary factor in Chinese essential hypertension.
作者
钟亚
哈黛文
Zhong Ya;Ha Daiwen(Department of Gerontology,Second Affiliated Hospital,Hubei Medical University,Wuhan 430071,China)
