摘要
探讨吸入一氧化氮（ＮＯ）对缺氧性肺动脉高压患者一氧化氮合酶（ＮＯＳ）和内皮素（ＥＴ）的影响。方法：１３例肺动脉高压患者行ＮＯ吸入，分别于吸入ＮＯ前、吸入３０ｍｉｎ时、停止吸入２ｈ和１２ｈ时采肺动脉血，测白细胞中的ＮＯＳ及血浆中的ＥＴ。结果：吸入ＮＯ前、吸入３０ｍｉｎ时、停止吸入２ｈ和１２ｈ，所测ＮＯＳ值分别为（０７０±０．２１）ｍｏｌ／ｍｉｎ·ｍｇ－１、（０７４±０１４）ｍｏｌ／ｍｉｎ·ｍｇ－１、（０６４±０２２）ｍｏｌ／ｍｉｎ·ｍｇ－１和（０６３±０１７）ｍｏｌ／ｍｉｎ·ｍｇ－１；所测ＥＴ为（７８８９±４６５９）ｐｍｏｌ／Ｌ、（８８２７±４５４１）ｐｍｏｌ／Ｌ、（８０７６±４２６６）ｐｍｏｌ／Ｌ和（６１０７±２９．４４）ｐｍｏｌ·Ｌ－１；后三者同吸入前比，均Ｐ＞００５。
Objective:To investigate the effects of nitric oxide (NO) inhalation on nitric oxide synthase (NOS) and endothelin (ET) of patients with hypoxic pulmonary hypertension. Methods:Examine the pulmonic blood samples in 13 cases to determine the concentration of NOS in leukocyte and ET in plasma before NO inhalation,30 minutes after the begining of inhalation, 2 and 12 hours after the stopping of inhalation respectively. Results:The value taken before inhalation was NOS(0.70±0.21) mon/min·mg -1 ,ET(78.89±46.59) pmol/L; taken at 30 minutes after the beginning NOS (0.74±0.14) mon/min·mg -1 ,ET(88.27±45.41) pmol/L;2 hours after stopping inhalation NOS (0.64±0.22) mon/min·mg -1 ,ET(80.76±42.66) pmol/L; and 12 hours after stopping of inhalation NOS (0.63±0.17) mon/min·mg -1 ,ET(61.07±29.44)pmol/L. no significant difference was found in the valve of NOS and ET before and after inhaltion, P >0.05.Conclusion:The effects of NO inhalation on NOS and ET in patients with hypoxic pulmonary hypertension are not significant according above investigation.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1998年第6期135-136,共2页
Journal of Jinan University(Natural Science & Medicine Edition)
