摘要
目的 探讨苏木水提物的抗癌作用机制。方法 分别采用腹腔注射、肌肉注射和灌胃等给药途径观察苏木水提物对小鼠移植性腹水瘤 EAC、白血病 P388、L12 10和肉瘤 S180的抑瘤作用 ,并进行了相应的体外抑瘤实验。结果 腹腔注射给药时高剂量组对各种腹水型移植瘤 (EAC、P388、L 12 10 )均有显著的抑制作用 ,但对实体瘤 S180无效。在相同剂量下肌肉注射及灌胃给药对各种移植瘤均未表现出抑瘤作用。体外抑瘤实验表明药物对各种瘤细胞均有一定的杀伤作用 ,且呈现出明显的量效相关性。结论 苏木水提物对癌细胞的杀伤作用是通过直接接触癌细胞而产生的 。
Objective To explore the anti cancer mechanism of aqueous extract of lignum sappan (AELS).Methods The control effect of AELS on transplanted tumors (EAC,P388,L1210 and S180) was observed in mice through three administration routes:intraperitoneal injection,intramuscular injection,and gavage;relevant in vitro carcinostatic tests were also made.Result Intraperitoneal AELS in its higher dosage exerted a notable inhibitory action on various transplanted ascitic tumours (EAC,P388,L1210),except on sarcoma S180.Intramuscular injection and gavage in the same dosage did not show any inhibitory action on the transplanted tumors.But the in vitro tests showed AELS has a certain cytocidal action on various tumor cells,and there was a close dose effect relationship found in the tests.Conclusion AELS exerts its tumoricidal and carcinostatic action only when it is directly in touch with the tumor cells;it will lose its effect when absorbed and catabolized in the body.
出处
《山西医药杂志》
CAS
2000年第3期201-203,共3页
Shanxi Medical Journal
关键词
苏木水提物
抗癌作用
靶细胞
给药途径
Aqueous extract of lignum sappan
Anti cancer
Mechanism of action
