3Chowdhury P S,Pastan I. Improve Antibody affinity by mimicking somatic hypermutation in vitro[J]. Nat Biotechnol, 1999,17 (6) :568-572.
4Marks J D, Hogenboom H R, Bonnert T P, et al. By passing immunization human antibody from v-gene libraries displayed on phage[J].J Mol Biol, 1991,222(3):581-597.
5Hawkins R E, Russell S J, Winter J. Selection of phage anti-bodies by binding affinity. Mimicking affinity maturation[J]. J Mol Biol,1992,226(3) : 889-896.
6Smith G P, Filamentous. Fusion phage novel expression vectors that display cloned antigens on the virion surface[J]. Science, 1985, 228(4705) :1315.
7Davies J, Richmann L. Antibody VH domains as small recongnition units[J]. Biotechnology,1996, 13(5) : 475-479.
8Markes J D, Hoogenboom H R, Bonrert T. P, et al. By passing immunization. Human antibodies from V-gene libraries displayed onphage[J]. J MolBiol,1991,222(3): 581-597.
9Barabas K,Sizensky JA,Faulk WP.Transferrin conjugates of adriamycin are cytotoxic without intercalating nuclear DNA.J Biol Chem,1992,267(13):9437-9442.
10Ohkawa K,Hatano T,Tsukada Y,et al.Chemotherapeutic efficacy of the protein-doxorubicin conjugates on multidrug resistant rat hepatoma cell line in vitro.Br J Cancer,1993,67(2):274-278.