摘要
应用免疫组织化学方法观察了８种肿瘤相关抗原（ＭＧ７、ＭＧｄ１、ＭＣ３、ＣＥＡ、涎酸化糖蛋白、ＣＡ１９─９、ＰＳ─４和ＴＡＧ─７２）在１１０例胃癌、３２例异型增生，１７３例萎缩性胃炎和２０例大致正常胃粘膜活检组织中的表达，发现胃癌组８种肿瘤相关抗原染色的阳性率显著高于良性病变和正常对照组（Ｐ＜０．０１～０．００１）。异型增生组和萎缩性胃炎组８种肿瘤相关抗原阳性率均显著高于正常对照组（Ｐ＜０．０５～０．０１）。除ＭＣ３外，各抗原在胎儿胃或肠粘膜均有部分阳性。以上结果说明，检测胃粘膜组织中的上述８种抗原，对胃癌的诊断和高危人群的筛选可能有重要意义。
Expression of 8 tumor-associated antigens(MG7,MGd1,MC3,CEA,Sialoglycoprotein,CA19-9, PS-4 and TAG-72)was investigated on 345 endoscopic biopsy specimens collected from patients with gastric cancer(n=110),dysplasia (n=32)and atrophic gastritis (n=173).Specimens of normal mucosa of the stomach (n=20),the small intestine (n=15) and the colon (n=20)were employed as the control.Specimens of gastric,intestinal and colonic mucosa of 10 aborted fetuses aged 16～24 weeks were also observed.All the specimens were fixed in 10% formalin,embedded in paraffin and stained by ABC immunohistochemical technique. The expression rates of 8 antigens in gastric cancer were significantly higher than those in dysplasia, atrophic gastritis and normal control(P<0.01～0. 001). The expression rates of 8 antigens in dysplasia and atrophic gastritis with intestinal metaplasia were significantly higher than those in the normal mucosa (P<0.05～0.01). The positive reaction with 8 antigens except for MC3 were also found in some specimens of fetal gastric, intestinal and colonic mucosa. Our results show that these 8 antigens were valuable tumor markers in diagnosis of gastric cancer and definition of the high-risk group of gastric cancer.
出处
《内镜》
1994年第5期259-262,共4页
关键词
癌
胃粘膜
活检
肿瘤相关抗原
胃肿瘤
Gastric cancer
biopsy of gastric mucosa
tumor-associated antigen
