摘要
应用间接酶标法对人体不同组织类型的61例肺癌进行了CEA单克隆抗体的免疫组化研究,鳞癌阳性率为92％,腺癌86.7％。CEA在鳞癌呈明显的细胞异质性分布,在同一癌巢中,仅位于癌巢中心、分化较好的细胞CEA阳性。CEA在鳞癌呈膜性分布;腺癌为胞浆分布。尽管鳞癌和腺癌CEA阳性率较高,但对其应用于示踪导向疗法的价值尚有待探讨。
Sixty-one human lung cancers of different histological type were studied with CEA-monoclonal antibody. The results showed that 92％ of squamous cell carcinoma were positive for CEA and 86.7％ of adenocarcinoma positive. CEA distribution in squamous cell carcinoma was variable and uneven. Positivity for CEA stain was only noted in well differentiated cells, i,e, the cells in the center of the cell nest. CEA in squamous cancer cell was limited at the cell membrane. In spite of the high positive percentage of CEA in squamous cell carcinoma andadenocarcinoma, the possibility of CEA being useful in target-oriented therapy of human lung cancer needs further study.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1991年第0期316-317,F002,共3页
Chinese Journal of Clinical Oncology
关键词
肺肿瘤
癌胚抗原
单克隆抗体
Lung cancer Carcinoembryonic antigen (CEA) Immunohistochemical technic CEA monoclonal antibody
