摘要
目的:探讨树莓酮(RK)对高血脂症大鼠血脂及血清炎症因子水平的调控作用。方法:40只雌雄各半的SD大鼠随机分为5组:正常对照组喂养普通饲料,高脂模型组喂养高脂饲料,RK高、中、低剂量组分别在喂养高脂饲料4周后给予20、10g/L和5g/L的树莓酮灌胃剂量,2mL/d。8周末处死各组大鼠,测定各组大鼠体质量、脏器指数、血脂(TC、TG、HDL-C、LDL-C)、载脂蛋白(ApoA-Ⅰ、ApoB)、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)等指标。结果:RK能显著降低高血脂症大鼠TC、TG、LDL-C水平,升高HDL-C水平,同时血清ApoA-Ⅰ水平亦显著升高,而ApoB水平显著降低;RK能降低高血脂症大鼠肝脏质量与体质量的比值;并能显著降低血清hs-CRP、TNF-α和IL-6等炎症因子水平。结论:RK具有调节高血脂症大鼠血脂的作用,并能改善高血脂症低度炎症状态。
Objective： to explore the effect of raspberry ketone （RK） on lipid metabolism and inflammatory factors in hyperlipidemic rats. Methods： forty SD rats （half male and half female） were randomly divided into 5 groups. The rats fed normal food were served as normal control group; the tats fed high-fat diets for 4 weeks were administered with RK at the doses of 20, 10 g/L and 5 g/L to create high, middle and low dose groups. The rats in each group were killed after the administration of RK for 8 week. The body weight, visceral index, and serum lipid parameters such as TC, TG, HDL-C and LDL-C, apolipoprotein including apoA-Ⅰ and apoB, C-reactive protein （hs-CRP）, TNF- α and IL-6 were determined. Results： RK could significantly reduce TC, TG and LDL-C levels in hyperlipidemic rats and increase HDL-C content. Meanwhile, serum apoA-Ⅰ level revealed a significant elevation while apoB revealed an obvious reduction. Moreover, RK could reduce the ratio between liver and body weight, and significantly reduce serum hs-CRP, TNF-α and IL-6 contents. Conclusion： RK not only has a role in regulating blood lipids but also can modulate low inflammation state in hyperlipidemlc rats.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2012年第13期267-270,共4页
Food Science
基金
辽宁省科技厅科技攻关计划项目(2011105001)
国家公益性行业(农业)科研专项(201103037)
