摘要
20例原发性垂体性侏儒症、2例单纯性GH缺乏IA型及1例宫内生长停滞的患儿用经典性药物进行激发试验并于夜睡眠中采血测GH,确认有GH缺乏。全部病例用重组hGH治疗。20例用191肽的Genotropin,3例用192肽的Somatonorm,疗程12个月(后一组中1例治疗6个月)。结果一年后身高增长Genotropin组为13.3±1.8cm,Somatonorm组2例各为16.0、16.6cm,1例治疗6个月后为7.9cm。疗程中出现血清T_4下降、轻度肝肿大、一过性血尿者各占47.8％、30.4％、30.4％。
Twenty patients (age 9.7±2.6 yrs) with primary pituitary dwarfism, two female sibs(age 8.4 and 11.7 yrs) with isolated growth hormone deficiency type IA (IGHD IA) and one girl (age 5.7 yrs) with intra-uterine growth retardation were investigated for the effect and side effect of recombinant growth hormone Genotropin or Somatonorm. The GH deficiency was defined as serum GH peak below 5 μg/L in two conventional pharmaceutical provocative tests associated with low GH level in sleep.
After one year treatment with Genotropin, the twenty patients with primary dwarfism got a growth of 13.3±1.8 cm while with Somatonorm the two sibs with IGHD IA had a height increment of 16.0 cm and 16.6 cm. The girl with intra-uterine growth retardation treated with Somatonorm for six months had a growth of 7.9 cm.
During the course of treatment low serum T4, mild liver enlargement and transient microscopic hematuria were found with incidence of 47.8%, 30.4% and 30.4% respectively without serious results.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1990年第4期198-200,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
γ-nGH
侏儒症
GHD
Recombmant human growth hormone Growth hormone deficiency dwarfisrn
