摘要
目的:正确评价重组人生长激素(rhGH)治疗儿童生长激素缺乏症(GHD)的疗效。方法:GHD患儿47例,给予rhGH0.1U/(kg.d),疗程3个月,并对其疗效进行观察。结果:身高(height)由(122±17.67)cm增至(125.32±17.50)cm,生长速率(growth rate)由<4cm/年增加到(10.40±3.74)cm/年。血清碱性磷酸酶(AKP)由(207±48.11)IU/L增至(261±45.29)IU/L。Ⅰ型前胶原羧基端伸展肽(PICP)由(97.80±14.94)ng/ml增至(119.50±24.10)ng/ml值。肌酐(Cr)由(40.20±8.28)umol/L变为(36.50±8.33)umol/L值。结论:rhGH是治疗GHD有效的药物。
Objective： To investigate the therapeutic effect of recombinant growth Recombinant growth hormone（rhGH）in growth Hormone deficient （GHD）children before adolescence. Methods： This study included 47 children （30 boys and 17 girls）with GHD, who were treated With subcutaneous injections of rhGH 0.1 U/ （kg. d） before sleep for 3 months. Results： The mean height form （ 122± 17.67 ） cm to（ 125.32± 17.50）cm, Growth rate by 〈4cm/year increased to （10.40± 3.74） / cm year, The mean AKP form（207± 48.11） 1U/L to （261± 45.29） 1U/L, The mean he PICP form （97.80± 14.94）ng/m to（119.50± 24.10） ng/ml, The mean Cr form（40.20± 8.28）umol/L to （36.50± 8.33）. Conclusions： Recombinant growth Ilormone（rhGil） is an effective ＆rug for promoting height growth in GIlD children.
出处
《现代生物医学进展》
CAS
2012年第28期5494-5496,共3页
Progress in Modern Biomedicine
关键词
生长激素缺乏症
重组生长激素
儿童
Growth Hormone deficiency
Recombinant growth Hormone
Children
