摘要
本文报告用重组hGH治疗9例特发性hGH缺乏儿童的疗效。治疗1年,身高生长速率由2.6±0.2增至10.7±0.5cm/年。剂量每周0.7 IU/kg、分7日皮下注射者比每周0.5 IU/kg、分3日肌肉注射者疗效更好。用药后除3例血清T_4降低,2例有未妨碍生长速度的抗hGH抗体外,无其他副作用。
This article describes the results of the 9 children with idiopathic GH deficiency treated with Somatonorm,the recom-binant hGH . The growth velocity increased from 2.6±0.2 to 10.7±0.5 cm / year after one year of treatment. The increment of the hGH level and the area under the response curve at the dose of 0.7 (IU / kg) / wk was more than that of 0.5 (IU / kg) / wk. The delayed bone age decreased from 6.2±0.5 to 5.4±0.4 years with no significant change. The serum SMC levels increased both on daily injection of Somatonorm for 4 days and during the whole year of this treatment on Somatonorm. The blood sugar levels and alkaline phosphatase concentrations increased significantly and no correlation was found between the increase of height and the serum SMC levels.
There was no local side effects and no abnormalitiaes in the routine blood and urine tests. Serum T4 of 3 patients dropped to the level below normal. Serum anti-hGH antibody appeared at third month in 2 patients and persisted to ,the end of the year, but it did not influence the growth velocity .
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1989年第1期7-10,共4页
Chinese Journal of Endocrinology and Metabolism
关键词
生长激素缺乏
儿童
侏儒
Idiopathic growth hormone deficiency Recombinant human growth hormone Short stature
