摘要
目的 :研究CD15、c erbB 2、PCNA和组织蛋白酶D(cathepsinD ,Cath D)表达与食管癌分级、浸润、转移和预后的关系 ,以及CD15表达与c erbB 2、PCNA和Cath D表达的相互关系。方法 :应用微波 SP免疫组化法 ,检测 6 5例食管鳞状细胞癌组织中CD15、c erbB 2、PCNA和Cath D表达水平。结果 :在食管癌中CD15、c erbB 2、PCNA和Cath D表达阳性率分别为 5 8 5 %、5 0 8%、6 9 2 %和 6 4 6 %。CD15、c erbB 2、PCNA和Cath D表达均与肿瘤分级、浸润、淋巴结转移和预后相关。CD15表达与c erbB 2、PCNA和Cath D表达呈正相关。结论 :CD15、c erbB 2、PCNA和Cath D是食管癌高度恶性和预后不良的重要生物学指标。食管癌CD15与c erbB 2、PCNA和Cath D表达具有相互协同作用可能。
Objective:To study the association of CD15 antigen expression with C erbB 2 protein,PCNA and cathepsin D(Cath D)in esophageal carcinoma Method:Microwave SP immunohistochemical method was used to examine the expression of CD15 antigen, C erbB 2 protein, PCNA and Cath D in 65 specimens of esophageal carcinoma Results:The positive rates of CD15 antigen, C erbB 2 protein, PCNA and Cath D were 58 5%, 50 8%, 62 9%and 64 6%respectively The expression of CD15 antigen, C erbB 2 protein, PCNA and Cath D were correlated with tumor grade,infiltration,lymph nodes metastasis and prognosis CD15 antigen expression was positively correlated with the expression of C erbB 2, PCNA and Cath D(r=0 42,r=0 45,P< 0 001) Conclusions:CD15 antigen ,C erbB 2 protein ,PCNA and Cath D expression are useful markers for determination of malignacy, poor prognosis, and lymph node metastasis of esophageal carcinoma There might be regulated interactively among CD15 antigen,C erbB 2 protein, PCNA and Cath D
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第5期453-455,共3页
Chinese Journal of Cancer
