摘要
目的 研究脑梗死患者血清 IL - 6含量变化及其意义。方法 我们用双抗体夹心 EL ISA法对 30例脑梗死患者的血清分别在发病 1d、3d、7d进行了连续检测 ,并用 2 0例健康人作对照。结果 发现脑梗死患者血清 IL -6含量在 3个时间点均高于对照组 (P<0 .0 5 )。在病程第 1d血清 IL- 6含量高于第 3d和第 7d(P<0 .0 5 ) ,且大面积脑梗死组血清 IL- 6含量高于小面积脑梗死组 ,神经功能受损重者血清 IL- 6含量高于神经功能受损轻者 (P<0 .0 5 )。结论 IL- 6在脑梗死中起重要作用 ,且 IL- 6水平与脑梗死面积、神经功能受损程度呈正相关。
Objective To investigate the change of interleukin 6(IL 6) in serum of patients with acute cerebrovascular disease. Methods The serum levels of IL 6 were measured by ELISA in 30 patients with cerebral infarction at day 1,day 3,day 7.and in 20 normal control. Results The levels of IL 6 in patient group were significantly higher at all the time points than the control(P<0.05). The peak was at 1d. The IL 6 level in patient group was positvely correlated with the infarct volume and the degree of neurological deficit. Conclusion IL 6 play an important role in the process of cerebral infarction.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2000年第2期91-92,共2页
Journal of Apoplexy and Nervous Diseases
关键词
脑梗塞
IL-6
血清
含量
Brain- infart
Interleukin- 6 (IL - 6 )
