摘要
目的探讨脑梗死患者血清白细胞介素-8(IL-8)水平与病程、梗死体积的关系。方法 采用ELISA法测定58例急性期、50例恢复期脑梗死患者的大体积组、小体积组的血清IL-8水平,并与20例健康人对照。结果脑梗死患者急性期血清IL-8水平较恢复期高(P<0 05),恢复期较健康对照组高(P<0.05),急性期和恢复期中的大体积组血清IL-8水平较小体积组高(P<0.01)。结论 血清IL-8水平与脑梗死发病后的病程呈负相关,与梗死体积呈正相关,血清IL-8水平可作为判断病情的有效指标。
Objective To investigate the relationship of the IL-8 in serum with the course of disease and infarct size in patients with cerebral infarction. Methods The IL-8 in serum was detected in 58 cases of patients during acute period and 50 cases during recovery period by the methods of ELISA, then compared with that of 20 cases of healthy persons. Results The level of IL-8 in serum in patients during acute period is higher than that during recovery period ( P <0.05), and patients in recovery period is higher than normal persons ( P < 0. 05). The level of IL-8 in serum in larger size infarction group is higher than that in smaller infarction size group ( P < 0. 01). Conclusions The IL-8 in serum has negative correlation with the course of cerebral infarction after onset, it has a positive correlation with the infarct size. The IL-8 in serum may be a effective parameter to judge the severity of this kinds of disease.
出处
《神经疾病与精神卫生》
2001年第2期10-11,共2页
Journal of Neuroscience and Mental Health
