摘要
近几年的研究表明,炎症反应是卒中后继发性损害的机制之一。急性卒中后缺血灶内及其周围存在明显的炎症细胞浸润和细胞因子表达增加,同时外周血白细胞、C-反应蛋白和各种细胞因子,如肿瘤坏死因子-α、白细胞介素-1和白细胞介素-6等水平增高。卒中并发的全身炎症反应综合征是导致多器官功能障碍综合征的主要发病基础。细胞因子的失控性释放在卒中并发全身炎症反应综合征向多器官功能障碍综合征的转化过程中起关键作用。
Studies in recent years have shown that inflammatory reaction is one of the mechanisms in secondary damage after stroke. In the ischemic foci and their surrounding tissues have significant inflammatory cell infiltration and increased expression of cytokine after acute stroke, at the same time, the levels of leukocyte, C-reactive protein, and various cytokines such as tumor necrosis factor-α, interleukin-1 and interleukin-6 increase. Stroke concomitant with systemic inflammatory response syndrome is the major pathogenic basis that results in multiple organ dysfunction syndrome. The uncontrolled release of cytokines plays a key role in the converting process from stroke concomitant with systemic inflammatory response syndrome to multiple organ dysfunction syndrome.
出处
《国际脑血管病杂志》
2006年第7期537-542,共6页
International Journal of Cerebrovascular Diseases
