摘要
目的 :探讨肺癌发病机制及早期监测指标 ,为多环芳烃作业人员劳动保护提供科学依据。方法 :对 5 1名多环芳烃类混合物接触者 (接触组 ) ,18例非肺癌患者 ,2 5例肺癌患者和 31名健康人员的血清脂质结合唾液酸(LSA)、谷胱甘肽S 转移酶 (GST)活性、超氧化物歧化酶同工酶 (SOD ,MnSOD和CuMnSOD)和T淋巴细胞亚群 (T3,T4,T8及T4/T8)进行测定。结果 :接触组、肺癌组和非肺癌组LSA均显著高于对照组 (P <0 .0 1)。接触组、非肺癌组和肺癌组GST显著高于对照组 (P <0 .0 5 )。肺癌组SOD显著高于非肺癌组 (P <0 .0 5 )。接触组、肺癌组和非肺癌组T3均显著低于对照组 (P <0 .0 5 ) ,接触组T3显著高于非肺癌组和肺癌组 (P <0 .0 5 ) ;接触组、非肺癌组和肺癌组T4均显著低于对照组 (P <0 .0 5 ) ,接触组T4显著高于非肺癌组 (P <0 .0 5 ) ;非肺癌组T4/T8显著低于对照组 (P <0 .0 1) ,接触组T4/T8显著高于非肺癌组 (P <0 .0 5 )。结论 :多环芳烃接触者生物膜出现了损伤性改变 ,免疫功能受到抑制。
Aim: To explore the mechanism and early monitoring index and supply scientific evidence of labor protection for workers who work in the environment containing pollutant of PAHs. Method: The method of professional epidemic was used to analyze lipid bound sialic acid (LSA) in serum, glutathione s transferase (GST), superoxide dismutase isoenzyme (SOD, Mn SOD and Cu Mn SOD) and T lymphoblast subgroup ( T3, T4, T8 and T4/T8). The experiment group included 51 cases who exposed to PAHs, 18 non lung tumor patients and 25 lung tumor patients. The control group was health persons. Results: The results showed that the LSA levels were significantly higher ( P <0.01) in exposure group (0.128±0.037), lung tumor group (0.147± 0.042 ) and non lung tumor group (0.129±0.054 ) than in control group (0.074±0.023). There were no marked difference ( P >0.05) between lung tumor group and exposure group, although the LSA level was higher in lung tumor group (0.147± 0.042 ) than in exposure group ( 0.128 ±0.037), and there was no significantly difference ( P >0.05) between exposure group ( 0.128 ±0.037) and non lung tumor group (0.129±0.054). The level of GST was notably higher ( P <0.05)in exposure group (32.15±9.73) than in control group ( 26.85 ±5.69). However, there were no marked difference ( P <0.05)between non lung tumor group(23.90±11.91) and lung tumor group(27.30±17.31), and between lung tumor group and control group (26.85±5.69). The level of SOD isoenzyme was significantly higher ( P <0.05) in lung tumor group (16.70±4.94) than in non lung tumor group (14.90±2.04), there were no significantly difference( P >0.05) between any other groups. The level was markedly lower in exposure group, lung tumor group (58.0±12.1) and non lung tumor group (57.4±10.1) than in control group ( 80.3 ±7.0)( P <0.01), the level was notably lower in non lung tumor (57.4±10.1) and lung tumor group (58.0±12.1) than in exposure group (68.7±9.0)( P <0.05). The level of T4 was significantly lower in exposure group (54.4± 9.3 ), non lung tumor group (46.8±9.3) and lung tumor group (50.4±11.5) than in control group (62.7±8.5)( P < 0.01 ), and lower remarkably in non lung tumor group than exposure group (p<0.01), but there was no notably difference between exposure group and lung tumor group ( P >0.05). The level of T4/T8 was significantly lower( P <0.05) in non lung tumor group(1.20± 0.31 ) than in control group (1.54±0.30), and significantly higher ( P <0.05) in exposure group (1.42±0.39) than non lung tumor group. There were no significantly difference between any other groups ( P >0.05). Conclusion: The results above mentioned demonstrated that in exposure group, LSA and GST increased , T3 and T4 decreased , and SOD was not changed markedly. The change tendency of LSA, T3 and T4 in exposure group agreed with in lung tumor group, but the level of LSA, T3 and T4 in exposure group were remarkably lower than in lung tumor group. The results also proved that the damage change of biomembrane of workers, who exposed to PAHs, occurred and the immunity function was repressed.
出处
《河南医科大学学报》
2000年第3期227-230,共4页
Journal of Henan Medical University
基金
河南省自然科学基金资助项目!973 3 0 0 0 1
关键词
职业接触
多环芳烃
T细胞亚群
肺肿瘤
polycyclic aromatic hydrocarbons
GST
SOD
sialic acid
T lymphoblast subgroup
