摘要
目的研究血清脂质结合唾液酸（ＬＳＡ）诊断肠恶性肿瘤的价值。方法采用血清ＬＳＡ快速测定法测定２４４例肠疾病患者血清ＬＳＡ。部分患者同时测定血清ＣＥＡ。结果癌症组ＬＳＡ（１４３±５２ｍｇ／Ｌ，ｎ＝５７）显著高于良性肿瘤和息肉组（９２±１６ｍｇ／Ｌ，ｎ＝２１），十二指肠溃疡组（８７±１６ｍｇ／Ｌ，ｎ＝２７），肠炎组（９２±２９ｍｇ／Ｌ，ｎ＝１００），及其它良性病组（９５±１６ｍｇ／Ｌ，ｎ＝２３）（Ｐ＜０．０１）。以ＬＳＡ＞１１５ｍｇ／Ｌ为检测阳性，则对肠癌症诊断敏感度、特异度、准确度依次为７３．７％，９０．１％与８６．０％；其敏感率和准确度均高于血清ＣＥＡ测定。癌症转移组ＬＳＡ阳性率显著高于未转移组；癌根除术后复发转移者全部ＬＳＡ阳性，未见复发或转移者全为阴性。结论血清ＬＳＡ对肠癌诊断。
AIMS To study the diagnostic value of serum lipid bond sialic acid (LSA) for intestinal malignacies. METHODS Serum LSA was quantitated in 244 patients with intestinal diseases by a fast method; and serum CEA was determined simultaneously in part of the patients. RESULTS Serum LSA level of malignancy group (143±52mg/L, n=57) was significantly higher than those of benign tumor and polyp (92±16mg/L, n=21), duodenal ulcer (87±16mg/L, n=27), enteritis (92±29mg/L, n=100), and other entero_disorders (95±16mg/L, n=23),(P<0.01). Taking LSA 115mg/L as positive sign of malignancy, the sensitivity, specificity and accuracy to diagnose entero_malignancies were 73.7%, 90.1% and 86.0%. The sensitivity and accuracy of LSA were higher than those of the CEA. The positivity of LSA in patients with metastases was much higher than that without metastases. In patients after surgical resection, the LSA was positive in all patients with tumor metastases or recurrence, but no positive one was found in those without metastases or recurence CONCLUSIONS Serum LSA is valubale in diagnosing entero_malignancies and supervising the metastases or recurence post resection.
关键词
肠癌
脂质
结合唾液酸
血清
诊断
sialic acids carcinoembryonic antigen intestinal neoplasms/diagnosis
