摘要
睾酮与孕酮配伍是有希望的可逆性男性避孕方案。最近的一项研究采用国产长效十一酸睾酮注射液 (2 5 0mg/mon)与国产长效左旋炔诺孕酮硅胶棒 (15 0mg)配伍 ,只造成约 40 %的受试者达到无精子。该研究在两名志愿者身上试用同样的配伍 ,但剂量均加倍 (睾酮 5 0 0mg/ 5wk ,左旋炔诺酮 30 0mg) ,结果维持了血清睾酮水平 ,抑制了血清促性腺激素LH和FSH ,两名受试者均达到无精子 ,且停药后精子数和促性腺激素水平恢复。因此推测这种配伍这种剂量是中国有希望的男性避孕方案 ,值得较大范围的进一步临床研究。
Combined administration of testosterone and progestin is a promising reversible male contraceptive regimens.A recent study using homemade long-term testosterone undecanoate injection (250mg/month) in combination with lervonorgestrel silastic implants (Sino-implants,2 rods,total dose 150mg) showed only 40%of men became azoospermic after treatment.The same combination with doubled doses of both testosterone (500mg/5 weeks)and levonorgestrel (300mg) was used in this study in two volunteers.The results demonstrated that serum testosterone levels were maintained,gonadotropins (LH and FSH) suppressed and azoospermia induced,and sperm counts and gonadotropins recovered after cessation of the treatment in both men.It was therefore speculated that combined use of testosterone and levonorgestrel might be a promising male contraceptive approach in China and worth further larger-scale clinical studies.
出处
《川北医学院学报》
CAS
2000年第1期4-6,共3页
Journal of North Sichuan Medical College
基金
四川省教委资助
关键词
十一酸睾酮
左旋炔诺孕
避孕
精子数
testosterone undecanoate
levonorgestrel silastic implants
men
contraception
sperm counts
gonadotropin
