摘要
目的:了解TTV与PHC的关系。方法:对82例PHC、40例非肝癌恶性肿瘤病人(对照组1)、40例正常人(对照组2)进行病例对照研究。结果:PHC组中,HBsAg、抗-HBe、HBeAg、HBV-DNA、HBV-M的阳性率分别为75.6％、51.2％、19.5％、28.0％、82.9％,显著高于两对照组,TTV-DNA阳性率26.8％(22/82)也显著高于两对照组。HBV感染率(82.9％)显著高于TTV的感染率(26.8％),在14例HBV阴性的PHC中,TTV-DNA阳性率达35.7％(5/14)。PHC病人中,若按HBV与TTV感染情况进行年龄分层,发现有HBV或TTV感染的病人,其发病年龄有提早的倾向;单纯HBV感染和与TTV混合感染其比值比(OR值)较两对照组明显升高。结论:广东地区TTV感染与PHC有关,TTV可能是PHC的一个致病因子,但HBV感染仍是主要的因素。
Aim: In order to understand the relationship of transfusion-transmitted virus (TTV) and primary hepatic carcinoma (PHC), Method: 82 patient with PHC, 40 with malignant tumours without evidence of liver involvement, and 40 normal controls were conducted by the case-control study. Results: Among patients with PHC the positive rates of HBsAg, anti-HBe, HBeAg, HBV-DNA, HBV-M were 75.6%, 51.2%, 19.5%, 28.0%, 82.9%, respectively. All of markers were higher than those detected in the other two groups. The positive rates of TTV in PHC patients were 26. 8% (22/82), that was higher than that of the other two groups, the positive rates of HBV-M (82. 9%) was higher than that of TTV-DNA. In the 14 of PHC patients who were no HBV infection, the positive rates of TTV-DNA was 35.7% (5/14). If we put the PHC patients at different age levels according to the status of HBV and TTV infection, there is tendency of early occurence of this heogrowth in simple HBV or TTV infection and also HBV and TTV mixed infections. In simple HBV and mixed with TTV patients, the Odds Ratio were higher than two control groups's. Conclusion : There results indicated that in Guangdong province, TTV infection might relate to PHC and play a possible role in the etiology of PHC, But HBV infection is still the major etiological factor.
出处
《中西医结合肝病杂志》
CAS
2000年第1期4-6,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
乙型肝炎病毒
TT病毒
原发性
肝癌
Hepatitis B Virus (HBV) Transfusion-Transmitted Virus (TTV) Hepatitis C Virus (HCV) Primary Hepatic Carcinoma (PHC)
