摘要
目的探讨血浆同型半胱氨酸(Hcy)及N-末端脑钠肽(NT-proBNP)水平与急性冠脉综合征(ACS)患者冠状动脉病变严重程度的相关性。方法 210例经冠状动脉造影证实的ACS患者根据Gensini评分系统对冠状动脉病变程度进行评分,并分为Gensini评分<30分组和≥30分组;根据冠状动脉病变支数分为单支病变组、双支病变组和三支病变组,采用ELISA法及电化学发光法测定血浆Hcy、NT-proBNP水平,分析Hcy、NT-proBNP与冠状动脉Gensini积分及病变支数的相关性。结果三支病变组及双支病变组Hcy及NT-proBNP均较单支病变组明显升高(P<0.05);Gensini积分≥30分组患者血浆Hcy及NT-proBNP水平显著高于Gensini积分<30分组(P<0.05);Hcy水平与冠状动脉病变支数及Gensini积分呈正相关关系(r=0.68,0.72,P<0.05),NT-proBNP水平与冠状动脉病变支数及Gensini积分亦呈正相关关系(r=0.77,0.83,P<0.05)。结论 ACS患者血浆Hcy及NT-proBNP水平与冠状动脉病变严重程度相关,二者随冠状动脉病变支数和病变严重程度的增加而逐渐升高。
Objectives To explore the correlation of plasma homocysteine（Hcy） and N-terminal probrain natriuretic peptide（NT-proBNP） with severity of coronary lesions in patients with acute coronary syndrome（ACS）.Methods A total of 210 ACS patients confirmed by coronary arteriongraphy were divided into groups 30-score and ≥30-score based on Gensini scores,and into groups 1-diseased-vessel,2-diseased-vessel,3-diseased-vessel according to number of diseased vessels.The levels of Hcy and NT-proBNP were determined by ELISA and electrochemiluminescence assay and correlations of Hcy and NT-proBNP with Gensini scores and number of diseased vessels were analyzed.Results The Hcy and NT-proBNP levels were higher in groups 2-and 3-diseased-vessel than in 1-diseased-vessel group（P0.05）,and higher in ≥30-score group than in 30-score group（P0.05）.Hcy was positively correlated with number of diseased vessels and Gensini scores（r=0.68,0.72,P0.05）,and NT-proBNP positively with number of diseased vessels and Gensini scores（r=0.77,0.83,P0.05）.Conclusion Hcy and NT-proBNP levels,correlated with severity of coronary lesions in ACS patients,gradually increase with the rise of number of diseased vessels and severity of coronary lesions.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第17期1935-1937,共3页
Chinese General Practice
