摘要
目的综合评价左旋甲状腺素(L-T4)治疗良性甲状腺结节的效果。方法检索1998-2011年在MED-LINE(PubMed)、万方数据库收录的相关文献及2005年1月至2010年12月国内中华内分泌学术会议的论文集。主要入选标准包括:1)随机对照研究;2)B超或彩超证实为单一或多发实质性结节,病理结果证实结节为良性病变;3)甲状腺功能在正常范围;4)均采用L-T4治疗;5)随访时间至少为6个月。结果入选的5篇文献共计353例患者,采用固定效应模型对患者用药前后甲状腺结节体积进行分析。与对照组相比,L-T4可以使甲状腺结节体积下降0.51mL,95%可信区间为0.11～0.90,P=0.01。未见心血管系统不良反应。结论 L-T4的治疗可缩小良性甲状腺结节的体积。
Objective To evaluate the effects of levothyroxine（L-T4） on benign thyroid nodules.Methods Three databases were searched to obtain reports on the effects of L-T4 on benign thyroid nodules：PubMed（1998-2011）,Wanfangdata（1998-2011） and China Proceedings of Endocrinology Cnference（January 2005-December 2010）.The main inclusion criteria were as follows：randomized controlled trial（RCT）;solitary or multiple substantial nodules proven by ultrasonography;benign lesion proven by biopsy;thyroid function in the normal range;all treated by L-T4;at least 6 months of follow-up.Results Five randomized trials were included（353 subjects）.The effects of L-T4 on thyroid nodule volume were analyzed with the fixed effect model.Compared with controls,thyroid nodule volume was decreased by 0.51 mL by treatment with L-T4（95% confidence interval,0.11-0.90,P=0.01）.No cardiovascular adverse reactions occurred in all cases.Conclusion L-T4 can effectively decrease the benign thyroid nodule volume.
出处
《南昌大学学报（医学版）》
CAS
2012年第3期28-30,41,共4页
Journal of Nanchang University：Medical Sciences
基金
江西省卫生厅科技计划(20111042)
