摘要
目的探讨小剂量左甲状腺素治疗良性甲状腺结节的临床有效性及安全性。方法对80例良性甲状腺结节患者的临床资料进行回顾性分析,依据治疗方法分为小剂量左甲状腺素治疗组(左甲状腺素组)和安慰剂治疗组(对照组)各40例。观察两组患者的临床疗效、甲状腺结节体积、血清甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(Ig T-PO-Ab)水平,以及不良反应发生情况。结果左甲状腺素组患者治疗后的总有效率明显高于对照组,差异有统计学意义(χ2=12.83,P<0.05)。左甲状腺素组患者治疗后的甲状腺结节体积明显小于治疗前和对照组治疗后,血清TSH水平明显低于治疗前和对照组治疗后,FT4水平明显高于治疗前和对照组治疗后,差异均有统计学意义(t分别=4.30、3.18、2.78、6.97、2.57、4.54,P均<0.05)。血清FT3、Ig T-PO-Ab水平在甲状腺素组患者治疗前后以及两组治疗后比较,差异均无统计学意义(t分别=1.53、1.48、0.12、0.06,P均>0.05)。左甲状腺素组患者的不良反应发生率明显低于对照组,差异有统计学意义(χ2=11.14,P<0.05)。结论小剂量左甲状腺素治疗良性甲状腺结节的临床有效性及安全性均较高。
Objective To investigate the clinical effectiveness and safety of low dose levothyroxine in the treatment of benign thyroid nodules. Methods The clinical data of 80 cases of patients with benign thyroid nodules were retrospectively analyzed. They were divided into the low dose levothyroxine treatment group and control group with40 cases in each two groups. The clinical efficacy,thyroid nodule volumes,serum TSH,FT3,FT4,Ig T-PO-Ab levels,and incidences of adverse reactions of the two groups were analyzed. Results The total treatment efficiency of the levothyroxine group after treatment was significantly higher than the control group（χ2=12.83,P 〈0.05）. The thyroid nodule volume of the levothyroxine group after treatment was significantly smaller than the control group and before treatment as well as the serum TSH level（t =4.30,3.18,2.78,6.97,P 〈0.05）,while the FT4 level was significantly higher than the control group（t=2.57,4.54,P〈0.05）.There were no differences in the serum FT3 and Ig T-PO-Ab levels of two groups before and after treatment as well as between two groups after treatment（t=1.53,1.48,0.12,0.06,P〉0.05）. The adverse reaction rate of levothyroxine group were significantly lower than the control group（χ2=11.14,P〈0.05）. Conclusion The low dose levothyroxine in the treatment of benign thyroid nodules has higher clinical efficacy and safety.
出处
《全科医学临床与教育》
2017年第5期525-527,共3页
Clinical Education of General Practice
